Ketoacidosis without glycosuria is seen in
Correct Answer: Prolonged starvation
Description: Starvation: In starvation, the dietary supply of glucose is decreased. Available oxaloacetate is channeled to gluconeogenesis. The increased rate of lipolysis is to provide alternate source of fuel. The excess acetyl CoA is conveed to ketone bodies. The high glucagon level ors ketogenesis. The brain derives 60-75% ofenergy from ketone bodies under conditions of prolonged starvation. Hyperemesis (vomiting) in early pregnancy may also lead to starvation-likecondition and may lead to ketosis. The urine of a patient with diabetic ketoacidosis will give positive Benedict&;s test as well as Rothera&;s test. But instarvation ketosis, Benedict&;s test is negative, but Rothera&;s test will be positive.Ref: DM Vasudevan - Textbook of Biochemistry, 6th edition, page no: 144 - 145
Category:
Biochemistry
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