Keshan cardiomegaly occur due to deficiency of
**Core Concept**
Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of **selenium** and the presence of a mutated strain of the **Coxsackievirus**. It primarily affects children and young women.
**Why the Correct Answer is Right**
The correct answer is related to the deficiency of **selenium**, an essential trace element that plays a crucial role in **antioxidant** defense systems, including **glutathione peroxidase**. Selenium deficiency can lead to oxidative damage and contribute to the development of Keshan disease.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because while other nutrients are important for heart health, they are not directly linked to Keshan disease.
**Option B:** Similarly, this option is incorrect as it does not specify the correct deficiency related to Keshan disease.
**Option C:** This option is also incorrect as it does not accurately represent the cause of Keshan cardiomegaly.
**Clinical Pearl / High-Yield Fact**
Keshan disease is a significant public health problem in certain regions with **selenium-deficient soil**, leading to low selenium levels in the food chain. Recognizing the role of selenium in preventing Keshan disease is crucial.
**Correct Answer:** D. Selenium