Keratan sulphate is found in abundance in
**Core Concept**
Keratan sulphate is a type of glycosaminoglycan, which is a key component of the **extracellular matrix**. It plays a crucial role in maintaining the structure and function of connective tissue. Keratan sulphate is particularly abundant in certain tissues.
**Why the Correct Answer is Right**
The correct answer is related to the specific distribution of keratan sulphate in the body. Keratan sulphate is found in high concentrations in the **cornea**, which is the transparent outer layer of the eye. This is because keratan sulphate helps to maintain the cornea's structure and transparency.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because while glycosaminoglycans are found in cartilage, keratan sulphate is not as abundant in cartilage as it is in other tissues.
**Option B:** This option is incorrect because keratan sulphate is not primarily found in bone.
**Option C:** This option is incorrect because although glycosaminoglycans are found in skin, keratan sulphate is more specifically associated with the cornea.
**Clinical Pearl / High-Yield Fact**
Keratan sulphate plays a critical role in maintaining the structure and function of the cornea, and its absence or alteration can lead to corneal disorders.
**Correct Answer:** D. Cornea.