Karyotype of complete molar pregnancy is
The core concept here is the chromosomal makeup. I think complete molar pregnancies are usually diploid, but with all the genetic material coming from the father. So, there's no maternal contribution. How does that happen? Oh right, in a complete mole, the egg is either enucleated or has an empty ovum. Then, a sperm fertilizes it, but there's some duplication of the paternal chromosomes. So the karyotype would be 46,XX or 46,XY, all paternal. Wait, but the egg doesn't contribute anything. So if the sperm fertilizes an empty egg, maybe there's a duplication of the paternal chromosomes. So the karyotype would be 46,XX if the sperm was X, or 46,XY if the sperm was Y. But since the egg has no maternal chromosomes, the entire set is paternal.
Now, the options are missing, but the correct answer in the user's example is not provided. However, based on standard knowledge, the correct karyotype for a complete mole is 46,XX or 46,XY all paternal. Partial moles usually have 69 chromosomes (triploid) with a mix of maternal and paternal contributions.
The wrong options would likely include other karyotypes like 45,X (Turner syndrome), 47,XXY (Klinefelter), or triploid 69. For a complete mole, the key is that it's diploid but entirely paternal. So if an option says 69,XXY or something like that, that's a partial mole or another condition.
Clinical pearl: Remember that complete moles are diploid paternal, partial moles are triploid. Also, complete moles have a higher risk of progressing to choriocarcinoma compared to partial moles. So the high-yield fact is the karyotype difference between complete and partial moles.
Putting this all together, the correct answer would be 46,XX or 46,XY with all paternal origin. If the options included these, then those would be correct. The user's correct answer is missing, but assuming the options are standard, the correct one is the diploid paternal karyotype.
**Core Concept**
A complete molar pregnancy arises from **abnormal fertilization** of an **enucleated oocyte** by a single sperm, which undergoes **diploid duplication** of paternal chromosomes. This results in a **46,XX or 46,XY karyotype** with **no maternal genetic contribution**. This contrasts with partial moles, which are triploid (69 chromosomes).
**Why the Correct Answer is Right**
In complete molar pregnancies, the oocyte is either enucleated or lacks maternal chromosomes. A single sperm fertilizes it and duplicates its own chromosomes (e.g., 23 paternal chromosomes β 46 total). This results in a **diploid paternal karyotype** (