**Core Concept**
Kartagener's syndrome is a rare genetic disorder that combines situs inversus (reversal of the major organs in the thorax and abdomen) with chronic sinusitis and bronchiectasis, resulting from mutations in the dynein axonemal heavy chain 9 (DNAH9) and other genes. This condition is part of a larger group of disorders known as primary ciliary dyskinesia (PCD), which affects the motility of cilia and flagella.
**Why the Correct Answer is Right**
The correct answer involves identifying the characteristic feature of Kartagener's syndrome that is not present. The syndrome is typically associated with situs inversus, chronic sinusitis, and bronchiectasis due to impaired ciliary function. The correct answer requires recognizing the absence of a specific feature among the options.
**Why Each Wrong Option is Incorrect**
**Option A:** Situs inversus is a hallmark of Kartagener's syndrome, so this option is incorrect.
**Option B:** Chronic sinusitis is a common feature of Kartagener's syndrome, making this option incorrect.
**Option C:** Bronchiectasis is a characteristic feature of Kartagener's syndrome, so this option is incorrect.
**Clinical Pearl / High-Yield Fact**
Primary ciliary dyskinesia (PCD) can be caused by mutations in multiple genes, including DNAH9, DNAH5, and others. These genes encode proteins that are essential for the proper functioning of cilia and flagella.
**Correct Answer: D.**
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