Kartagener syndrome all true except-
**Core Concept**
Kartagener syndrome is a rare genetic disorder characterized by a triad of situs inversus, bronchiectasis, and chronic sinusitis, resulting from mutations in the dynein arm genes that disrupt ciliary function.
**Why the Correct Answer is Right**
The correct answer is related to the underlying pathophysiology of Kartagener syndrome, which involves impaired ciliary motility due to mutations in the dynein arm genes. This leads to reduced clearance of mucus and bacteria from the respiratory tract, resulting in chronic infections and inflammation. The situs inversus is a result of the abnormal embryonic development due to the defective ciliary function.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because Kartagener syndrome is indeed associated with chronic sinusitis, which is a result of the impaired ciliary function leading to reduced clearance of mucus and bacteria from the sinuses.
**Option B:** This option is incorrect because bronchiectasis is a characteristic feature of Kartagener syndrome, resulting from the chronic inflammation and infection due to impaired ciliary function.
**Option C:** This option is incorrect because situs inversus is a hallmark feature of Kartagener syndrome, resulting from the abnormal embryonic development due to the defective ciliary function.
**Clinical Pearl / High-Yield Fact**
Kartagener syndrome is a classic example of a primary ciliary dyskinesia (PCD), which is a group of genetic disorders characterized by impaired ciliary function leading to chronic respiratory infections and situs inversus.
**Correct Answer:** D