**Core Concept**
Korsakoff's Psychosis is a neuropsychiatric disorder characterized by profound anterograde and retrograde amnesia, with impaired formation of new memories and difficulty recalling past events. This condition is often associated with chronic alcohol abuse and thiamine deficiency.

**Why the Correct Answer is Right**
Korsakoff's Psychosis primarily affects the hippocampus and surrounding structures, leading to impaired long-term memory consolidation. The pathophysiology involves damage to the medial temporal lobe and diencephalon, resulting in the characteristic memory deficits. Thiamine deficiency disrupts the normal functioning of the brain's neurotransmitter systems, particularly acetylcholine and glutamate, which play crucial roles in memory formation.

**Why Each Wrong Option is Incorrect**
**Option A:** Peripheral neuropathy is a common complication of chronic alcohol abuse but is not a diagnostic feature of Korsakoff's Psychosis.
**Option B:** Visual hallucinations can occur in various psychiatric and neurological conditions but are not a primary characteristic of Korsakoff's Psychosis.
**Option D:** Seizures are not a hallmark of Korsakoff's Psychosis, although they can be seen in other forms of chronic alcohol-related brain damage.

**Clinical Pearl / High-Yield Fact**
Korsakoff's Psychosis is often described as a "wet brain" syndrome, highlighting the critical role of thiamine supplementation in preventing and treating this condition. A high index of suspicion for Korsakoff's Psychosis should be maintained in patients with a history of chronic alcohol abuse and memory impairments.

✓ Correct Answer: C. Impairment of long term memory