**Core Concept**
The question refers to the joint that is typically spared in Rheumatoid Arthritis (RA), a chronic autoimmune disorder characterized by inflammation and destruction of joints. In RA, the synovial membrane lining the joints becomes inflamed, leading to joint damage and deformity.

**Why the Correct Answer is Right**
The joint that is spared in RA is the first carpometacarpal joint of the thumb. This is because the synovial membrane of this joint is relatively thin and fibrous, making it less susceptible to the inflammatory process seen in RA. The other joints, such as the metacarpophalangeal joints and the proximal interphalangeal joints, are commonly affected in RA due to their thicker and more synovial-lined joints.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because the metacarpophalangeal joints are commonly affected in RA, leading to symptoms such as swelling, pain, and stiffness.
**Option B:** This option is incorrect because the proximal interphalangeal joints are also commonly affected in RA, resulting in deformities such as swan neck and boutonniere deformities.
**Option C:** This option is incorrect because the wrist joint is a common site for RA involvement, leading to symptoms such as pain, stiffness, and decreased range of motion.
**Option D:** This option is incorrect because the ankle joint is not a typical site for RA involvement, although it can be affected in some cases.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that the joints most commonly affected in RA are the metacarpophalangeal joints, proximal interphalangeal joints, and the wrists. The first carpometacarpal joint of the thumb is typically spared, making it a key differentiator from other forms of arthritis.

**Correct Answer:** C. Wrist.