**Core Concept**
Jamais vu is a French term that describes a feeling of unfamiliarity or strangeness when experiencing something that is actually familiar. It is a psychological phenomenon where an individual feels as though they are experiencing a situation or event for the first time, even if they have encountered it before.

**Why the Correct Answer is Right**
Jamais vu is often associated with temporal lobe abnormalities, particularly in the hippocampus and amygdala, which are critical for memory formation and emotional processing. The feeling of unfamiliarity in situations or events that are familiar is thought to be due to disruptions in the normal functioning of these brain regions. This can be seen in individuals with temporal lobe epilepsy, where episodic memory and emotional processing are impaired.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because déjà vu, not jamais vu, is the feeling of familiarity in a situation or event that is actually unfamiliar.
**Option B:** This option is incorrect because it is a description of a different psychological phenomenon, not jamais vu.
**Option C:** This option is incorrect because it is a description of a different type of memory or cognitive process, not jamais vu.

**Clinical Pearl / High-Yield Fact**
Jamais vu can be a symptom of various neurological and psychiatric conditions, including temporal lobe epilepsy, psychiatric disorders, and certain types of dementia. It is essential to consider this phenomenon in the context of a patient's overall clinical presentation and medical history.

**Correct Answer: D. Jamais vu is a feeling of unfamiliarity or strangeness in familiar situations or events.**