**Question:** Iris pearl are seen in -

A. Uveitis
B. Corneal ulcer
C. Trauma
D. Endophthalmitis

**Core Concept:**
Iris pearl refers to the presence of pearl-like, yellowish lesions on the iris, which are indicative of a specific clinical condition. These pearls are formed due to the accumulation of lipofuscin granules within the iris pigment epithelial cells. Lipofuscin is a breakdown product of cellular pigments that accumulates with age or in certain pathological conditions.

**Why the Correct Answer is Right:**
The correct answer, D. Endophthalmitis, refers to the inflammation of the vitreous cavity and the inner layer of the eye (hyaloid membrane). In endophthalmitis, the iris becomes inflamed due to the release of inflammatory mediators and infiltration of immune cells. This leads to the formation of iris pearls as a result of lipofuscin accumulation in the iris pigment epithelial cells.

**Why Each Wrong Option is Incorrect:**
A. Uveitis (option A) refers to inflammation within the uveal tract of the eye, which is not the same as endophthalmitis. Uveitis does not result in iris pearl formation due to different underlying causes and inflammation patterns.

B. Corneal ulcer (option B) is a condition involving the cornea, which is distinct from the iris and does not lead to the formation of iris pearls.

C. Trauma (option C) is a broad category that can cause various ocular injuries, but the formation of iris pearls is not a common sequelae of eye trauma.

**Clinical Pearl:**
Understanding the clinical pearls and pearls in ophthalmology helps in differentiating between various ocular conditions. Iris pearls are a helpful sign to recognize endophthalmitis, a crucial differential diagnosis in cases of acute iris swelling or inflammation.