## Core Concept
The iridocorneal endothelial (ICE) syndrome is a rare ocular disorder characterized by the abnormal growth of corneal endothelial cells onto the iris and trabecular meshwork. This condition leads to secondary glaucoma and is often associated with iris atrophy and corneal edema.

## Why the Correct Answer is Right
The ICE syndrome is primarily linked to **trabecular meshwork** dysfunction due to the abnormal proliferation of corneal endothelial cells. These cells grow onto the iris and trabecular meshwork, causing increased intraocular pressure (IOP) through impaired aqueous outflow. The correct answer relates to the structure primarily involved in the pathogenesis of ICE syndrome.

## Why Each Wrong Option is Incorrect
* **Option A:** While the **iris** is involved in ICE syndrome, manifesting as iris atrophy or irregularities, it is not the primary site associated with the syndrome's pathogenesis.
* **Option B:** The **cornea** is the origin of the abnormal endothelial cells in ICE syndrome, but the primary issue is not the cornea itself but rather the extension of these cells to other structures.
* **Option C:** The **lens** is not directly involved in the primary pathophysiology of ICE syndrome.

## Clinical Pearl / High-Yield Fact
A key clinical pearl is that ICE syndrome often presents unilaterally and is more common in young to middle-aged adults, particularly females. A classic feature is the presence of **iris atrophy**, which can be sectoral or diffuse.

## Correct Answer Line
**Correct Answer: D. Trabecular meshwork.**