**Core Concept**
Iridocorneal endothelial (ICE) syndrome is a rare condition characterized by the proliferation of abnormal corneal endothelial cells, leading to corneal edema, iris atrophy, and glaucoma. This condition is often associated with a poor prognosis and requires prompt management to prevent vision loss.
**Why the Correct Answer is Right**
The correct answer is related to the characteristic features of ICE syndrome. The condition is typically characterized by a combination of corneal edema, iris atrophy, and a characteristic pattern of iris changes, including posterior iris atrophy and a "corkscrew" or "feathery" iris. The correct answer should be a feature that is not typically associated with ICE syndrome.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because corneal edema is a hallmark feature of ICE syndrome, resulting from the abnormal proliferation of corneal endothelial cells.
**Option B:** This option is incorrect because iris atrophy is a common finding in ICE syndrome, often associated with a "corkscrew" or "feathery" appearance of the iris.
**Option C:** This option is incorrect because glaucoma is a common complication of ICE syndrome, resulting from the abnormal proliferation of corneal endothelial cells and subsequent iris damage.
**Clinical Pearl / High-Yield Fact**
ICE syndrome is often associated with a poor prognosis, and prompt management is essential to prevent vision loss. A thorough understanding of the characteristic features of this condition is crucial for accurate diagnosis and treatment.
**Correct Answer: D.**
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