The investigative method of choice for confirmation of H.pylori eradication is
**Core Concept**
The confirmation of Helicobacter pylori (H. pylori) eradication is crucial in managing patients with peptic ulcer disease or gastritis. H. pylori is a bacterium that infects the stomach lining and can cause various gastrointestinal disorders. The investigative method of choice should be able to accurately detect the presence or absence of H. pylori in the stomach.
**Why the Correct Answer is Right**
The urea breath test (UBT) is the most commonly used method for confirming H. pylori eradication. This test is based on the enzyme urease, which is produced by H. pylori. Urease breaks down the urea in the breath test solution into carbon dioxide and ammonia. The carbon dioxide is then exhaled and measured by a breath analyzer. If H. pylori is present, the urease will break down the urea, and the breath test will be positive. The UBT is non-invasive, quick, and accurate, making it the preferred method for confirming eradication after treatment.
**Why Each Wrong Option is Incorrect**
* **Option B:** Serum H. pylori IgG antibody test is not suitable for confirming eradication because the antibodies may persist for months after treatment, leading to false-positive results.
* **Option C:** Stool antigen test can be used for diagnosing H. pylori infection but is not the preferred method for confirming eradication due to potential false-negative results.
* **Option D:** Endoscopy with biopsy is an invasive procedure that may be used to diagnose H. pylori infection but is not necessary for confirming eradication.
**Clinical Pearl / High-Yield Fact**
The urea breath test is a simple, non-invasive, and accurate method for confirming H. pylori eradication. It is essential to perform the UBT at least 4-6 weeks after completing treatment to ensure accurate results.
**Correct Answer: C. Stool antigen test can be used for diagnosing H. pylori infection but is not the preferred method for confirming eradication due to potential false-negative results.