A male patient was undergoing routine health checkup and investigations when a lump was incidentally diagnosed on clinical examination. Clinician advised USG following which USG guided biopsy was done. HPE examination revealed the following diagnosis. Patient was staed on chemotherapy including a drug obtained from the given plant. What is the site of action of the drug mentioned above?
A male patient was undergoing routine health checkup and investigations when a lump was incidentally diagnosed on clinical examination. Clinician advised USG following which USG guided biopsy was done. HPE examination revealed the following diagnosis. Patient was staed on chemotherapy including a drug obtained from the given plant. What is the site of action of the drug mentioned above?
💡 Explanation
**Core Concept**
The patient is likely diagnosed with a type of cancer, and the drug obtained from a plant is used in chemotherapy to target rapidly dividing cancer cells. This concept involves understanding the mechanism of action of plant-derived chemotherapeutic agents.
**Why the Correct Answer is Right**
The plant-derived drug is likely derived from the plant Vinca rosea, commonly known as Madagascar periwinkle. The active ingredient is Vinblastine, which acts as a microtubule inhibitor. It binds to tubulin and prevents the formation of microtubules, thereby inhibiting cell division and inducing apoptosis in rapidly dividing cancer cells. This mechanism is crucial in targeting cancer cells that are rapidly dividing.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as it does not specify the site of action of the drug.
**Option B:** This option is incorrect as it does not relate to the site of action of the drug in the context of chemotherapy.
**Option C:** This option is incorrect as it does not accurately describe the site of action of the drug.
**Clinical Pearl / High-Yield Fact**
Plant-derived chemotherapeutic agents like Vinblastine are often used to target rapidly dividing cancer cells. These agents can be effective in treating various types of cancers, including Hodgkin's lymphoma and childhood leukemia.
**Correct Answer:** C. Microtubules.
✓ Correct Answer: A. B
📤 Share this MCQ
Share Card Preview
👆 1080x1080 square card — fills the full width in WhatsApp and Telegram