A hospital has reported an outbreak of MRSA infection. On investigation, it was found that staff nurses and doctors had nasal carriage of MRSA. Which of the following drug helps in removal of colonization of bacteria?
**Core Concept**
The MRSA outbreak is linked to nasal carriage among healthcare workers, highlighting the importance of decolonization to prevent transmission. Decolonization involves eliminating or reducing the bacterial load on the skin and mucous membranes.
**Why the Correct Answer is Right**
The correct answer involves the use of mupirocin, a topical antibiotic that inhibits bacterial protein synthesis. Mupirocin targets isoleucyl-tRNA synthetase, an enzyme essential for bacterial growth, thereby reducing the colonization and transmission of MRSA. By applying mupirocin nasal ointment, healthcare workers can effectively decolonize themselves and prevent the spread of MRSA in the hospital.
**Why Each Wrong Option is Incorrect**
**Option A:** Chlorhexidine is an antiseptic used for skin disinfection, but it is not effective in decolonizing MRSA from the nasal mucosa.
**Option B:** Ciprofloxacin is a broad-spectrum antibiotic that can be used to treat MRSA infections, but it is not the preferred choice for decolonization due to potential resistance development.
**Option C:** Triclosan is an antiseptic used in hand sanitizers and soaps, but it is not effective in decolonizing MRSA from the nasal mucosa.
**Clinical Pearl / High-Yield Fact**
To effectively decolonize MRSA, healthcare workers should use a combination of nasal mupirocin ointment and chlorhexidine gluconate skin cleanser, and maintain good hand hygiene practices.
**Correct Answer: C. Mupirocin.