A topical retinoid recently introduced for the treatment of psoriasis is :
**Core Concept**
Topical retinoids are a class of medications derived from vitamin A, used to treat various skin conditions by promoting cell turnover, reducing inflammation, and preventing keratinization.
**Why the Correct Answer is Right**
The correct answer is a topical retinoid that specifically targets the pathophysiology of psoriasis, which involves abnormal keratinocyte proliferation and differentiation. This medication works by inhibiting the enzyme 4-oxoreductase, which is involved in the conversion of retinol to retinoic acid, thereby reducing inflammation and preventing keratinization. The correct answer is also known to have a favorable safety profile and is effective in treating mild to moderate psoriasis.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as it is not a topical retinoid and has not been approved for the treatment of psoriasis.
**Option B:** This option is incorrect as it is a different class of medication used to treat psoriasis, but not a topical retinoid.
**Option C:** This option is incorrect as it is a systemic retinoid, not topical, and is used for severe psoriasis, not mild to moderate cases.
**Clinical Pearl / High-Yield Fact**
When treating psoriasis, topical retinoids are often used in combination with other medications, such as corticosteroids or calcineurin inhibitors, to achieve better results and minimize side effects.
**Correct Answer: B. Tazarotene**