Intrauterine seizure in foetus is seen due to deficiency of
**Core Concept**
Intrauterine seizures in a fetus are a rare but serious condition that can be caused by various factors, including metabolic disorders. The underlying principle being tested is the relationship between fetal metabolic disorders and their effects on fetal brain function.
**Why the Correct Answer is Right**
Fetal intrauterine seizures are often associated with congenital disorders of fatty acid oxidation, such as medium-chain acyl-CoA dehydrogenase (MCAD) deficiency. This deficiency leads to the accumulation of toxic intermediates, which can disrupt normal brain function and cause seizures. The pathophysiology involves the impaired breakdown of fatty acids, leading to energy deficits and neuronal excitability.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because homocystinuria is a disorder of amino acid metabolism, which is not directly related to intrauterine seizures.
**Option B:** This option is incorrect because phenylketonuria is a disorder of amino acid metabolism that can cause developmental delays, but it is not typically associated with intrauterine seizures.
**Option C:** This option is incorrect because galactosemia is a disorder of carbohydrate metabolism, which can cause developmental delays and other complications, but it is not typically associated with intrauterine seizures.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that congenital disorders of fatty acid oxidation can present with a range of symptoms, including intrauterine seizures, hypoglycemia, and cardiomyopathy. A high index of suspicion is necessary for early diagnosis and management.
**Correct Answer:** D.