## **Core Concept**
Topical corticosteroids used in ophthalmology can have systemic and local side effects, including the potential to increase intraocular pressure (IOP). This effect is particularly concerning as it can lead to steroid-induced glaucoma. The risk varies among different corticosteroids.

## **Why the Correct Answer is Right**
The correct answer, **D. Dexamethasone**, has a high potency and a longer duration of action, which correlates with a higher risk of increasing intraocular pressure. Dexamethasone is a potent synthetic corticosteroid known for its significant anti-inflammatory and immunosuppressive properties. Its high potency and prolonged use can lead to a substantial increase in IOP in susceptible individuals.

## **Why Each Wrong Option is Incorrect**
- **Option A:** This option is incorrect because, although it may have some effect on IOP, its potency and risk of increasing IOP are lower compared to dexamethasone.
- **Option B:** This option is incorrect as it might not be as potent as dexamethasone in terms of IOP elevation.
- **Option C:** This option is incorrect because its effect on IOP, while present, is generally considered less than that of dexamethasone.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that the risk of increasing intraocular pressure is higher with more potent steroids and those used for prolonged periods. **Dexamethasone** and **betamethasone** are considered to have a higher risk of causing steroid-induced glaucoma. Clinicians should monitor IOP in patients on long-term topical corticosteroid therapy.

## **Correct Answer:** **D. Dexamethasone**