Most common site of primary for intraocular metastasis is from:(AIIMS November 2013, May 2013)
**Core Concept**
The question requires knowledge of the common sites of primary tumors that metastasize to the eye, specifically the intraocular structures. Intraocular metastasis refers to the spread of cancer cells to the uvea, which includes the choroid, ciliary body, and iris. The question is testing the student's understanding of the most common primary sites that metastasize to the intraocular structures.
**Why the Correct Answer is Right**
Breast cancer is the most common primary site for intraocular metastasis. This is because breast cancer cells can spread to the eye through the hematogenous route, where they lodge in the choroid, a highly vascularized layer of the eye. The choroid is rich in blood vessels, which provides a conducive environment for the growth of metastatic cancer cells. The high vascularity of the choroid also explains why intraocular metastasis is more common in the choroid compared to other intraocular structures.
**Why Each Wrong Option is Incorrect**
* **Option A:** Lung cancer is a common primary site for metastasis, but it is not the most common site for intraocular metastasis. Lung cancer cells can metastasize to the eye, but they are more likely to spread to the orbit or the eyelids rather than the intraocular structures.
* **Option B:** Melanoma is a primary ocular tumor that can spread to the orbit or the brain, but it is not typically associated with intraocular metastasis.
* **Option D:** Colorectal cancer can metastasize to the eye, but it is not the most common primary site for intraocular metastasis.
**Clinical Pearl / High-Yield Fact**
The most common primary sites for intraocular metastasis are breast, lung, and melanoma. However, breast cancer is the most common primary site, accounting for approximately 50% of all cases of intraocular metastasis.
**Correct Answer: D. Breast cancer**