**Question:** What is not true about the use of intranasal steroids in nasal polyposis?

**Core Concept:** Intranasal steroids are a class of medications used to reduce inflammation and alleviate symptoms in patients with nasal polyposis. They work by inhibiting the production of pro-inflammatory mediators and reducing vascular permeability.

**Why the Correct Answer is Right:** Intranasal steroids are generally effective in the treatment of nasal polyposis due to their anti-inflammatory properties. However, option E (not mentioned) is correct because it addresses a specific limitation of intranasal steroids.

**Why Each Wrong Option is Incorrect:**

A. **Intranasal steroids are ineffective:** This is incorrect as they do have anti-inflammatory effects and can improve symptoms.
B. **Intranasal steroids cause significant systemic absorption:** While systemic absorption does occur, it is generally low, and the majority of the drug remains localized in the nasal cavity.
C. **Intranasal steroids do not reduce the size of nasal polyps:** Intranasal steroids primarily act on the local inflammatory process, leading to symptomatic relief but not a complete reduction in polyp size.
D. **Intranasal steroids cause adrenal suppression:** This is a rare occurrence, and the risk is lower when using low-potency steroids and short-term therapy.

**Intranasal steroids (E):**

**Clinical Pearl:** While intranasal steroids are beneficial in managing nasal polyposis, they may not fully resolve the condition due to their localized action on inflammation.

**Correct Answer:** E (Intranasal steroids do not fully resolve nasal polyps)