Which of the following are intracellular events occurring in fibroblast during synthesis of collagen?
**Core Concept**
The synthesis of collagen involves a series of intracellular and extracellular events. Intracellularly, it begins with transcription of collagen genes and translation of mRNA into polypeptide chains, which then undergo several post-translational modifications.
**Why the Correct Answer is Right**
The correct answer involves the process of hydroxylation of proline and lysine residues, glycosylation, and formation of triple helix structure, all of which occur intracellularly. These modifications are crucial for the stability and function of collagen.
**Why Each Wrong Option is Incorrect**
**Option A:** This choice is incorrect because it does not accurately describe the specific intracellular events related to collagen synthesis in fibroblasts.
**Option B:** Similarly, this option does not correctly identify the key steps in the intracellular synthesis of collagen.
**Option D:** This option is also incorrect as it does not specify the correct intracellular processes involved in collagen synthesis.
**Clinical Pearl / High-Yield Fact**
Collagen synthesis disorders can lead to significant clinical conditions, such as Ehlers-Danlos syndrome and osteogenesis imperfecta, highlighting the importance of understanding collagen synthesis.
**Correct Answer:** C. Hydroxylation and glycosylation of proline and lysine residues.