**Core Concept**
Vitamin D intoxication occurs when there is excessive intake or production of vitamin D, leading to hypercalcemia, which can cause various symptoms and complications. The body's response to vitamin D intoxication involves the regulation of calcium levels through the parathyroid hormone (PTH) and the vitamin D receptor (VDR) pathways.

**Why the Correct Answer is Right**
The correct answer is related to the pathophysiology of vitamin D intoxication. Vitamin D intoxication causes an increase in serum calcium levels, which can lead to symptoms such as nausea, vomiting, and constipation. The kidneys play a crucial role in excreting excess calcium, and in the case of vitamin D intoxication, they can become overwhelmed, leading to hypercalcemia. The PTH and VDR pathways are also affected, as PTH levels can remain suppressed, and VDR-mediated calcium absorption is increased.

**Why Each Wrong Option is Incorrect**
**Option A:** Hypercalcemia is a hallmark of vitamin D intoxication, making this option incorrect.
**Option B:** Muscle weakness can occur in vitamin D deficiency, but it is not a characteristic feature of vitamin D intoxication.
**Option C:** Polyuria can occur in vitamin D intoxication due to the effects of hypercalcemia on the kidneys.

**Clinical Pearl / High-Yield Fact**
A key clinical feature of vitamin D intoxication is the suppression of PTH levels, which can make it challenging to diagnose and treat.

**Correct Answer:** B.