Impaired Glucose intolerance is caused by deficiency of
## **Core Concept**
Impaired glucose tolerance (IGT) is a pre-diabetic state characterized by higher than normal blood glucose levels but not high enough to be classified as diabetes mellitus. This condition often results from insulin resistance or impaired insulin secretion. The underlying principle here involves glucose metabolism and insulin action.
## **Why the Correct Answer is Right**
The correct answer, **. Glucokinase**, is related to glucose metabolism in the liver. Glucokinase plays a crucial role in glucose utilization in the liver by facilitating the phosphorylation of glucose to glucose-6-phosphate, a key step in glucose metabolism. A deficiency in glucokinase leads to an impaired ability to take up glucose in the liver, contributing to elevated blood glucose levels, which is a hallmark of impaired glucose tolerance.
## **Why Each Wrong Option is Incorrect**
- **Option A:** This option is incorrect because while related to metabolic pathways, it does not directly relate to the primary cause of impaired glucose tolerance.
- **Option B:** This option is incorrect as it does not directly impact glucose tolerance in the same way glucokinase does.
- **Option D:** This option is incorrect because, although important in glucose metabolism, its deficiency does not directly cause impaired glucose tolerance.
## **Clinical Pearl / High-Yield Fact**
A notable condition related to glucokinase deficiency is maturity-onset diabetes of the young type 2 (MODY 2), characterized by an autosomal dominant inheritance pattern and typically presents with mild hyperglycemia.
## **Correct Answer:** . Glucokinase