Interstitial cells (of Leydig) in testes secrete which of the following:March 2011
**Core Concept**
Interstitial cells of Leydig are a type of cell found in the testes, responsible for producing and secreting a key hormone involved in male reproductive physiology. These cells are named after Franz von Leydig, who first described them in the 1850s.
**Why the Correct Answer is Right**
The correct answer is testosterone, a steroid hormone produced by the Leydig cells. Testosterone plays a crucial role in the development of male reproductive organs, secondary sex characteristics, and sperm production. The Leydig cells produce testosterone through the action of the enzyme cholesterol desmolase, which converts cholesterol into pregnenolone, a precursor molecule in the synthesis of testosterone. This process is essential for maintaining male fertility and overall reproductive health.
**Why Each Wrong Option is Incorrect**
* **Option A:** Inhibin is a protein hormone produced by Sertoli cells in the testes, not interstitial cells of Leydig. Inhibin plays a role in regulating FSH secretion.
* **Option B:** Androstenedione is a steroid hormone produced by the adrenal glands and ovaries, but not primarily by Leydig cells. It is a precursor to testosterone.
* **Option D:** Progesterone is a steroid hormone involved in the female menstrual cycle and pregnancy, not a primary product of Leydig cells.
**Clinical Pearl / High-Yield Fact**
Remember that Leydig cells are sensitive to luteinizing hormone (LH) from the pituitary gland, which stimulates testosterone production. This is why LH levels are often measured in patients with hypogonadism or infertility.
**Correct Answer: C. Testosterone**