‘Intermediate form’ of Non hodgkin’s lymphoma is ?
**Core Concept**
Non-Hodgkin's lymphoma (NHL) is a diverse group of cancers originating from the lymphatic system, characterized by the uncontrolled growth of lymphocytes. The World Health Organization (WHO) classification system categorizes NHL into several subtypes based on their cell of origin, genetic features, and clinical behavior.
**Why the Correct Answer is Right**
The intermediate form of NHL is typically referred to as Follicular lymphoma (FL). FL is a type of B-cell lymphoma that arises from the germinal center B cells. It is characterized by the presence of a t(14;18) chromosomal translocation, which leads to the overexpression of BCL-2 protein, an anti-apoptotic protein that promotes cell survival and proliferation. This results in the accumulation of malignant follicular center B cells in the lymph nodes, spleen, and bone marrow.
**Why Each Wrong Option is Incorrect**
**Option A:** MALT lymphoma is a type of marginal zone B-cell lymphoma, typically presenting as a low-grade lymphoma.
**Option B:** Diffuse large B-cell lymphoma (DLBCL) is an aggressive form of NHL, often presenting with a high-grade histology and rapid progression.
**Option C:** Mantle cell lymphoma is a rare type of B-cell lymphoma that typically presents with a t(11;14) translocation and a more aggressive clinical course.
**Clinical Pearl / High-Yield Fact**
Follicular lymphoma often presents with a nodal mass, and its diagnosis is confirmed by the presence of a characteristic "centrocyte" morphology on histopathology, along with the t(14;18) translocation.
**Correct Answer: C. Mantle cell lymphoma is a rare type of B-cell lymphoma that typically presents with a t(11;14) translocation and a more aggressive clinical course.