Insulin-like growth factor-II (IGF-II) is synthesized in all EXCEPT:
Correct Answer: Cailage
Description: GH actions of growth of bones and visceral organs are mediated by a group of hormones/factors called insulin-like growth factors (IGFs). It is a complex system that includes: Two ligands (IGF-I and IGF-II), two cell membrane receptors for these ligands (IGF-IR and IGF-IIR) . IGF-I is the major form produced in most adult tissues; IGF-I is for achieving maximal growth. IGF-I is produced by and influences many cells in the body, especially cells in muscle, cailage, bone, liver, kidneys, nerves. IGF- II is the major form produced in the fetus. IGF-II is the growth factor for early (fetal) growth and development; IGF-II is produced by brain, kidney, pancreas, and muscle. Both IGFs are produced by the liver, in response to a GH stimulus. {Among the options given in this question, cailage synthesizes IGF-I. Hence, it is the answer.}
Category:
Physiology
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