**Core Concept**
Insulin plays a crucial role in regulating glucose and lipid metabolism. In the context of lipogenesis, insulin stimulates the synthesis of fatty acids from acetyl-CoA, a process that is essential for energy storage and lipid homeostasis. This process involves the activation of key enzymes and transcription factors that facilitate the conversion of glucose to fatty acids.

**Why the Correct Answer is Right**
Insulin promotes lipogenesis by activating the following key enzymes and pathways:
- **Acetyl-CoA carboxylase (ACC)**: Insulin stimulates the phosphorylation and activation of ACC, which is the rate-limiting enzyme in fatty acid synthesis.
- **Fatty acid synthase (FAS)**: Insulin also promotes the expression and activation of FAS, which is responsible for the elongation of acetyl-CoA into long-chain fatty acids.
- **SREBP-1c**: Insulin stimulates the activation of SREBP-1c, a transcription factor that regulates the expression of genes involved in lipogenesis.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because insulin does indeed stimulate lipogenesis through the activation of ACC and FAS.
**Option B:** This option is incorrect because insulin promotes lipogenesis by activating SREBP-1c, which is a key transcription factor in this process.
**Option C:** This option is incorrect because insulin does indeed stimulate lipogenesis through the activation of ACC and FAS.

**Clinical Pearl / High-Yield Fact**
Insulin resistance, often seen in type 2 diabetes, impairs lipogenesis and leads to an accumulation of fat in adipose tissue, contributing to the development of insulin resistance and metabolic syndrome.

**Correct Answer: D.**