Hypoglycemia in hyperinsulinmic state require IM glucagon as treatment. Glucagon increases glucose level in blood by Glycogenolysis and Gluconeogenesis. But in galactosemia - Liver is the first organ to be affected, so glucagon will unable to increase glucose as glycogenolysis and gluconeogensis can not occur ion already damaged liver.Nesidioblastosis :It is persistent hyperinsulinemic hypoglycemia occurs due to 0 - cell hypertrophy in infant of diabetic mother due to continuous maternal hyperglycemia. Glucagon is effective in controlling such a hypoglycemic condition.