True statement about inheritance of an X linked recessive trait is –
**Core Concept**
Inheritance of X-linked recessive traits is a pattern of genetic transmission where the mutated gene responsible for the condition is located on the X chromosome. Affected males typically express the condition, while affected females are usually carriers, exhibiting milder symptoms or none at all.
**Why the Correct Answer is Right**
X-linked recessive traits are more common in males because they have only one X chromosome. If this X chromosome carries the mutated gene, the male will express the condition. Females, on the other hand, have two X chromosomes, so even if one X chromosome carries the mutated gene, the other X chromosome can compensate for the mutation, resulting in milder or no symptoms. This is why female carriers often exhibit reduced or no symptoms. The affected male usually has a 50% chance of passing the mutated gene to each daughter, who will become carriers, and a 50% chance of passing the normal X chromosome to each daughter, who will be unaffected. Sons, however, will only inherit the mutated gene if their mother is a carrier, resulting in 50% of sons being affected.
**Why Each Wrong Option is Incorrect**
**Option A:** This option may be incorrect as it does not specify the correct pattern of inheritance.
**Option B:** This option may be incorrect as it does not accurately describe the inheritance pattern of X-linked recessive traits.
**Option C:** This option may be incorrect as it does not correctly describe the inheritance pattern of X-linked recessive traits.
**Clinical Pearl / High-Yield Fact**
It is essential to remember that the inheritance pattern of X-linked recessive traits affects males more frequently than females, and female carriers can pass the mutated gene to their sons, who will be affected, and their daughters, who will be carriers.
**Correct Answer: C.**