In which pattern does inheritance of Dupuytren’s contracture takes place?
**Core Concept**
Dupuytren's contracture is a fibrotic disorder characterized by the formation of nodules and cords in the palmar fascia, leading to flexion deformity of the fingers. The underlying pathophysiology involves the abnormal proliferation and contraction of fibroblasts, resulting in the formation of these nodules and cords.
**Why the Correct Answer is Right**
The inheritance pattern of Dupuytren's contracture is complex and multifactorial, involving both genetic and environmental factors. Studies have shown that there is a significant familial predisposition, with a higher incidence in first-degree relatives of affected individuals. The genetic component is thought to be polygenic, with multiple genetic variants contributing to the risk of developing the condition. This complex inheritance pattern is consistent with an autosomal dominant pattern of inheritance, where a single copy of the mutated gene is sufficient to increase the risk of developing the condition.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because Dupuytren's contracture does not follow a simple Mendelian pattern of inheritance.
* **Option B:** This option is incorrect because there is no evidence to suggest that Dupuytren's contracture is inherited in an autosomal recessive pattern.
* **Option D:** This option is incorrect because while there may be some environmental factors that contribute to the development of Dupuytren's contracture, the primary inheritance pattern is not due to environmental influences.
**Clinical Pearl / High-Yield Fact**
Dupuytren's contracture is more common in individuals of European descent, particularly those of British or Irish ancestry. This may be due to the genetic predisposition of these populations, as well as environmental factors such as smoking and manual labor.
**Correct Answer:** C.