**Core Concept**
Kinky hair disease, also known as Menkes disease, is a rare genetic disorder characterized by sparse, coarse, and steely hair, along with intellectual disability, seizures, and failure to thrive. It is caused by mutations in the ATP7A gene, which is responsible for copper transport and homeostasis in the body.

**Why the Correct Answer is Right**
In this family, the disease is inherited in an X-linked recessive pattern. The affected males (sons of Mrs. A's sisters) have a 50% chance of inheriting the mutated gene from their mother, who is likely a carrier. The mother's affected uncle also supports this pattern, as he would have inherited the mutated gene from his mother (Mrs. A's grandmother). Female carriers, like Mrs. A's sisters and mother, typically do not show symptoms but can pass the mutated gene to their sons.

**Why Each Wrong Option is Incorrect**
**Option B:** X-linked dominant inheritance would result in affected females (grandmother, mother, and sisters) and affected males (sons), which contradicts the given family history.
**Option C:** Autosomal recessive inheritance would require both parents to be carriers for their offspring to be affected, which is not the case in this family.
**Option D:** Autosomal dominant inheritance would result in affected males and females in each generation, which is not consistent with the pattern observed in this family.

**Clinical Pearl / High-Yield Fact**
In X-linked recessive disorders, affected males typically do not pass the mutated gene to their sons, as they inherit only one X chromosome. However, they can pass the mutated gene to all their daughters, who become carriers.

**✓ Correct Answer: A. X-linked recessive**