True/false statements about inflammatory bowel disease- pending Mucosal granularity is earliest finding seen in ulcerative colitis Coomb sign is seen in UC. Lead pipe colon is seen in UC. Fibrosis and strictures are more common in UC. Apthous ulcers are earliest finding seen in CD.
**Core Concept**
Inflammatory bowel disease (IBD) encompasses chronic conditions characterized by inflammation of the gastrointestinal tract, primarily Crohn's disease (CD) and ulcerative colitis (UC). Mucosal granularity, Cobblestone appearance, and lead pipe colon are distinct radiological findings that help differentiate between the two conditions.
**Why the Correct Answer is Right**
Ulcerative colitis is characterized by an earliest finding of mucosal granularity, which is due to the diffuse inflammation and edema of the colonic mucosa. This granularity is a result of the thickening of the mucosal layer, making it appear coarse and uneven. In contrast, Crohn's disease typically presents with cobblestone appearance due to deep longitudinal and transverse ulcers. The lead pipe colon is a radiological feature of UC, resulting from the diffuse inflammation and shortening of the colon. Fibrosis and strictures are indeed more common in UC due to the chronic inflammation and scarring.
**Why Each Wrong Option is Incorrect**
**Option A:** Pending Mucosal granularity is earliest finding seen in ulcerative colitis - **Incorrect**, as Cobblestone appearance is the earliest finding in Crohn's disease.
**Option B:** Coomb sign is seen in UC - **Incorrect**, as Coomb sign is actually a radiological feature seen in Crohn's disease, not UC.
**Option C:** Lead pipe colon is seen in UC - **Incorrect**, while lead pipe colon is indeed more common in UC, it is not exclusive to UC and can be seen in other conditions.
**Option D:** Fibrosis and strictures are more common in UC - **Incorrect**, fibrosis and strictures are more common in Crohn's disease due to the transmural inflammation and scarring.
**Clinical Pearl / High-Yield Fact**
The distinction between UC and CD can be challenging, and a combination of clinical features, endoscopic findings, and radiological features is crucial for diagnosis.
**Correct Answer:** A.