A 15-year-old girl was admitted to the infectious disease hospital with a provisional diagnosis of rabies. The most suitable clinical sample that can confirm the antemoem diagnosis is –
**Core Concept**
The diagnosis of rabies, a fatal viral disease, relies on the detection of the virus or its antigens in clinical samples. The most suitable sample should ideally be obtained before the onset of clinical symptoms, making antemortem diagnosis challenging. However, certain samples can provide evidence of the infection.
**Why the Correct Answer is Right**
The correct answer is **CSF (Cerebrospinal Fluid)**, which is the most suitable clinical sample for confirming antemortem diagnosis of rabies. This is because the virus can be detected in the CSF before the onset of clinical symptoms, allowing for early diagnosis and treatment. The viral antigens or nucleic acid can be identified using techniques such as PCR (Polymerase Chain Reaction) or immunofluorescence.
**Why Each Wrong Option is Incorrect**
* **Option A:** Blood sample is not the most suitable sample for diagnosing rabies, as the virus is not consistently detectable in the blood.
* **Option B:** Saliva sample can be used for postmortem diagnosis, but it is not suitable for antemortem diagnosis.
* **Option C:** Skin biopsy is not a commonly used method for diagnosing rabies.
**Clinical Pearl / High-Yield Fact**
It is essential to note that the diagnosis of rabies should be made in conjunction with clinical symptoms and epidemiological history, as the virus can be present in the body without causing symptoms.
**Correct Answer:** C. CSF (Cerebrospinal Fluid)