Infant with cystic fibrosis (CF) are likely to develop –
**Core Concept**
Cystic fibrosis is a genetic disorder caused by mutations in the CFTR gene, leading to abnormal chloride transport across epithelial cells. This results in thickened mucus production and impaired clearance, affecting various organs, including the lungs, pancreas, and liver.
**Why the Correct Answer is Right**
Infants with cystic fibrosis are prone to developing meconium ileus, a condition where the meconium is thick and sticky, causing intestinal obstruction. This occurs due to the abnormal chloride transport in the intestinal epithelium, leading to dehydration of the meconium. The meconium becomes inspissated, causing an obstruction in the ileum.
**Why Each Wrong Option is Incorrect**
**Option A:** Gastroesophageal reflux disease (GERD) is not a direct consequence of cystic fibrosis, although some patients may develop GERD due to delayed gastric emptying.
**Option B:** Pancreatitis is a possible complication of cystic fibrosis, but it is not the most common gastrointestinal issue in infants with CF.
**Option C:** Intussusception is a potential complication of cystic fibrosis, but it is not as directly related to the disease as meconium ileus.
**Clinical Pearl / High-Yield Fact**
Meconium ileus is a classic presentation of cystic fibrosis in newborns, and its presence should prompt further investigation for CF, including genetic testing and sweat chloride analysis.
**Correct Answer:** C.