Pharmacology Indomethacin can antagonize the diuretic action of loop diuretics by: A Preventing prostaglandin mediated intrarenal-hemodynamic actions B Blocking the action in ascending limb of loop of Henle C Enhancing salt and water reabsorption in distal tubules D Increasing aldosterone secretion 💡 Explanation Indomethacin can antagonize the diuretic action of loop diuretics by: ✓ Correct Answer: A. Preventing prostaglandin mediated intrarenal-hemodynamic actions