Increased proliferation of cells is called:
**Core Concept**
Increased cell proliferation is a fundamental concept in pathology and physiology, referring to the enhanced growth and division of cells, often in response to various stimuli such as growth factors, hormones, or injury. This process is crucial in development, healing, and tissue repair, but can also contribute to disease states like cancer.
**Why the Correct Answer is Right**
The correct answer is **hyperplasia**. Hyperplasia involves the increased number of cells in a tissue, often leading to an enlarged organ or tissue mass. This is in contrast to hypertrophy, where the size of cells increases without a change in cell number. Hyperplasia occurs through the activation of cell cycle regulatory proteins, such as cyclin-dependent kinases, which drive the cell cycle forward. Key enzymes and pathways involved in hyperplasia include the PI3K/AKT pathway and the cyclin-dependent kinase inhibitor p21.
**Why Each Wrong Option is Incorrect**
* **Option A:** Hypertrophy refers to the increase in size of cells, not the number of cells. While hypertrophy can occur in response to similar stimuli as hyperplasia, it does not involve the proliferation of new cells.
* **Option B:** Metaplasia is the replacement of one cell type with another, often in response to chronic irritation or injury. While metaplasia can involve changes in cell number, it is not characterized by increased cell proliferation.
* **Option C:** Dysplasia refers to disordered or abnormal cell growth, often associated with precancerous changes. Dysplasia can involve increased cell number, but it is not a direct synonym for hyperplasia.
**Clinical Pearl / High-Yield Fact**
Remember the classic distinction between hyperplasia and hypertrophy: hyperplasia involves an increase in cell number, while hypertrophy involves an increase in cell size. This is crucial in diagnosing and understanding the pathophysiology of various diseases.
**Correct Answer:** C. Hyperplasia.