Increased LDH in Aqueous Humor suggest a diagnosis of –
**Core Concept**
Increased lactate dehydrogenase (LDH) in the aqueous humor is indicative of intraocular inflammation or injury, often associated with conditions like uveitis or retinal detachment. This elevation occurs due to the breakdown of retinal cells and the subsequent release of LDH into the aqueous humor.
**Why the Correct Answer is Right**
The correct answer is related to the pathophysiology of increased LDH in the aqueous humor. LDH is an enzyme that catalyzes the conversion of lactate to pyruvate and is present in various tissues, including the retina. In conditions like uveitis, the inflammation and damage to the retina lead to the release of LDH into the aqueous humor, causing an increase in its levels. This is a specific and sensitive indicator of intraocular inflammation.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not relate to the specific context of increased LDH in the aqueous humor. While cataracts can cause changes in the aqueous humor, they are not directly associated with elevated LDH levels.
**Option B:** This option is incorrect because glaucoma is a condition primarily associated with increased intraocular pressure, which is not directly related to the increase in LDH levels in the aqueous humor.
**Option C:** This option is incorrect because retinal detachment is a condition that can cause changes in the aqueous humor, but it is not the most specific or direct cause of increased LDH levels.
**Clinical Pearl / High-Yield Fact**
It is essential to remember that increased LDH in the aqueous humor is a specific indicator of intraocular inflammation or injury, and it can be used as a diagnostic tool in conditions like uveitis.
**Correct Answer: C. Retinal detachment**