Activity of all of the following enzymes is increased in diabetes state except
**Core Concept**
In diabetes, various metabolic pathways are altered due to hyperglycemia, leading to increased activity of certain enzymes involved in glucose metabolism. The enzymes in question are crucial for breaking down glucose and generating energy in the body.
**Why the Correct Answer is Right**
The correct answer is one of the enzymes that is not involved in glucose metabolism or is not increased in activity in diabetes. In diabetes, the activity of enzymes such as **hexokinase** and **phosphofructokinase** is increased to compensate for the high glucose levels. Hexokinase is the first enzyme in the glycolytic pathway, converting glucose into glucose-6-phosphate. Phosphofructokinase is another key enzyme in glycolysis, catalyzing the conversion of fructose-6-phosphate into fructose-1,6-bisphosphate.
**Why Each Wrong Option is Incorrect**
**Option A:** Hexokinase is indeed increased in activity in diabetes to facilitate glucose uptake and utilization by cells.
**Option B:** Phosphofructokinase is also increased in activity in diabetes to compensate for the high glucose levels and generate energy.
**Option C:** Glucose-6-phosphatase is actually decreased in activity in diabetes, as it is involved in gluconeogenesis and glycogenolysis, which are pathways that generate glucose in the liver.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that in diabetes, the body's goal is to utilize glucose as efficiently as possible to generate energy. This is why enzymes involved in glycolysis, such as hexokinase and phosphofructokinase, are increased in activity.
**Correct Answer:** C. Glucose-6-phosphatase