**Core Concept:** Incontinentia Pigmenti (IP) is a rare autosomal dominant disorder affecting the skin, hair, teeth, and central nervous system, with an approximate incidence of 1 in 23,000 females. It is caused by mutations in the NEMO gene, which is part of the nuclear factor kappa B (NF-κB) signaling pathway.

**Why the Correct Answer is Right:** Inheritance of Incontinentia Pigmenti follows an autosomal dominant pattern. This means that if one parent with the mutated NEMO gene is affected, there is a 50% chance of transmitting the disorder to their offspring. In this case, the correct answer (D) is referring to autosomal dominant inheritance, which is the mode of inheritance for Incontinentia Pigmenti.

**Why Each Wrong Option is Incorrect:**

A. Autosomal Recessive Inheritance: In autosomal recessive disorders, both parents need to have the mutated gene for their child to inherit the condition. In IP, this mode of inheritance is incorrect.

B. X-linked Dominant Inheritance: IP is an autosomal dominant disorder, not X-linked.

C. X-linked Recessive Inheritance: This mode of inheritance is incorrect for IP, which is an autosomal dominant disorder.

**Clinical Pearl/High-Yield Fact:** Autosomal dominant disorders like Incontinentia Pigmenti make it possible for an unaffected parent to pass on the condition to their child, emphasizing the importance of genetic counseling for couples where one partner has a genetic disorder.