**Core Concept**
Rabies is a viral disease caused by the rabies virus, primarily transmitted through the saliva of infected animals, usually dogs. The virus affects the central nervous system (CNS) and is characterized by distinct clinical features.

**Why the Correct Answer is Right**
The correct answer is B. Hemotogenous spread to brain because rabies is primarily transmitted through nerve tissue, not through hematogenous (bloodborne) spread to the brain. The virus enters the body through the bite wound, and from there, it travels up the peripheral nerves to the CNS, causing the characteristic symptoms of rabies. The virus multiplies in the salivary glands and eventually reaches the CNS, where it causes inflammation and damage to the brain.

**Why Each Wrong Option is Incorrect**
**Option A:** Ascending paralysis is indeed a characteristic feature of rabies, as the virus causes inflammation and damage to the CNS, leading to muscle weakness and paralysis that often begins in the face and spreads down the body.
**Option C:** Rabies can be transmitted through bites other than dogs, including cats, bats, raccoons, and other animals that carry the virus. This is why post-exposure prophylaxis (PEP) is essential after any animal bite.
**Option D:** Although rabies is almost invariably fatal if left untreated, prompt medical attention and post-exposure prophylaxis can prevent the disease from developing in people who have been bitten by an infected animal.

**Clinical Pearl / High-Yield Fact**
It's essential to recognize the characteristic features of rabies, including ascending paralysis, hydrophobia, and agitation, to provide prompt medical attention and prevent the spread of the disease.

✓ Correct Answer: B. Hemotogenous spread to brain