In Wilson’s disease, all are seen except
**Core Concept**
Wilson's disease is a rare genetic disorder characterized by excessive accumulation of copper in the body, particularly in the liver, brain, and other vital organs. This accumulation leads to oxidative stress, inflammation, and cellular damage, resulting in various clinical manifestations.
**Why the Correct Answer is Right**
Wilson's disease is caused by mutations in the ATP7B gene, which encodes a copper-transporting P-type ATPase responsible for regulating copper levels in the liver. The disease presents with a variety of symptoms, including liver disease (cirrhosis, hepatitis), neurological symptoms (tremors, rigidity, dystonia), psychiatric symptoms (depression, anxiety), and Kayser-Fleischer rings (copper deposition in the cornea). The disease is often diagnosed through a combination of clinical evaluation, laboratory tests (such as serum ceruloplasmin levels, 24-hour urine copper excretion), and imaging studies (such as MRI or CT scans).
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is not a characteristic of Wilson's disease.
**Option B:** This option is incorrect because it is not a primary feature of Wilson's disease, although some patients may experience weight loss due to liver disease or malabsorption.
**Option C:** This option is incorrect because it is not a typical manifestation of Wilson's disease, although some patients may experience tremors or other movement disorders due to basal ganglia damage.
**Clinical Pearl / High-Yield Fact**
Wilson's disease is often referred to as "hepatolenticular degeneration" due to its association with liver disease and neurological symptoms. Kayser-Fleischer rings, a hallmark of the disease, are a result of copper deposition in the cornea and can be detected through slit-lamp examination.
**Correct Answer: A.**