ACE inhibitors have been shown to reduce moality in chronic hea failure, hypeension, and diabetic renal disease * ACE inhibitors and ARBs increase the risk of hyperkalemia in CKD and with supplemental K+ or K+-sparing drugs. ACE inhibitors and ARBs should be discontinued during pregnancy as they cause fetal kidney damage.ACE inhibitors may cause acute renal failure paicularly in patients with bilateral renal aery stenosis or stenosis of the renal aery of a solitary kidneyKatzung Pharmacology 12th edition Pg: 185