In well fed state, the activity of Carnitine Palmitoyl Transferase-1 in outer mitochondrial membrane is inhibited by:

Correct Answer: Malonyl-CoA
Description: Ans. C. Malonyl-CoA(Ref Harper 31/e page 214)Fatty acid oxidation is inhibited in the well fed state because, CPT-I activity is low in fed state because of inhibition by malonyl-CoA, the initial intermediate in fatty acid synthesis formed by acetyl-CoA carboxylase.
Category: Biochemistry
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