**Question:** In Turner's syndrome which of the following is NOT seen:

A. Short stature
B. Ovarian failure
C. Spinal cord abnormalities
D. Hypothyroidism

**Core Concept:**
Turner's syndrome is a genetic disorder characterized by partial or complete monosomy of the second chromosome (45,X). It results in various clinical manifestations, including short stature, ovarian failure, and hypothyroidism. The condition is typically associated with cardiovascular, renal, and skeletal abnormalities.

**Why the Correct Answer is Right:**
Option D, Hypothyroidism, is not typically seen in Turner's syndrome. Hypothyroidism is caused by dysfunction or deficiency of thyroid hormones, which is unrelated to the chromosomal abnormality in Turner's syndrome. In contrast, the other options are directly related to the chromosomal abnormality and its resulting clinical manifestations.

**Why Each Wrong Option is Incorrect:**
A. Short stature: Turner's syndrome is characterized by short stature due to growth hormone deficiency and impaired longitudinal bone growth.
B. Ovarian failure: Turner's syndrome results in primary ovarian insufficiency, leading to amenorrhea and infertility.
C. Spinal cord abnormalities: While Turner's syndrome can cause spinal deformities, such as scoliosis, this is not specific to this condition and can be seen in other genetic disorders as well.

**Clinical Pearl:**
Turner's syndrome is a valuable example of how chromosomal abnormalities can lead to a range of clinical manifestations. It highlights the importance of considering genetic disorders in patients with seemingly unrelated symptoms. A thorough clinical examination, genetic counseling, and appropriate investigations are essential for proper diagnosis and management of Turner's syndrome.