In thromboasthenia there is a defect in –
Correct Answer: Platelet aggregation
Description: Platelet adhesion
Platelet adhesion referes to the binding of platelets to subendothelial matrix.
Platelet membrane glycoprotein Ib-IX is essential for platelet adhesion to subendothelial matrix.
Platelet aggregation
Platelet aggregation referres to adherence of platelets to one another.
Platelet membrane glycoprotein ddb-IIIa helps in aggregation.
Congenital dysfunction of platelet
1. Bernard-soulier syndrome
Defect in platelet adhesion due to inherited deficiency of glycoprotein Ib-IX.
2. Glanzmann's thrombasthenia
Defect in platelet aggregation due to inherited deficiency of glycoprotein Ilb-IIIa.
Category:
Pediatrics
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