Pharmacology In the treatment of undiagnosed megaloblastic anemia, vitamin B12 and folic acid should be given together because: A Vitamin B12 acts as a cofactor for dihydrofolate reductase B Folic acid alone causes improvement of anemic symptoms but neurological dysfunction continues. C Vitamin B12 deficiency may result in methylfolate trap D Folic acid is required for conversion of methylmalonyl-CoA to succinyl CoA. 💡 Explanation In the treatment of undiagnosed megaloblastic anemia, vitamin B12 and folic acid should be given together because: ✓ Correct Answer: B. Folic acid alone causes improvement of anemic symptoms but neurological dysfunction continues.