**Core Concept:** Testicular Feminization Syndrome is a rare condition caused by defects in the SRY gene, which leads to the absence of testes development in males. In such cases, testicular abnormality is present, and the affected individual presents with primary amenorrhea, gynecomastia, and infertility. Gonadectomy refers to the surgical removal of gonads (testes or ovaries).

**Why the Correct Answer is Right:**
In Testicular Feminization Syndrome, the absence of testicular function results in the inability to produce testosterone, the primary male sex hormone. This leads to the characteristic features of gynecomastia, primary amenorrhea, and infertility. The primary goal of gonadectomy is to address these clinical manifestations by removing the source of estrogen production, which is the dysfunctional testes. Estrogen levels will decrease after gonadectomy, leading to reduced gynecomastia, improved secondary sexual characteristics, and potential resolution of infertility.

**Why Each Wrong Option is Incorrect:**
A. Ovariectomy (removal of ovaries): This option is incorrect because ovariectomy would not address the primary issue of Testicular Feminization Syndrome, which is the absence of testicular function. Ovariectomy would not alleviate the symptoms associated with low testosterone levels.
B. Gonadectomy: This option is incorrect because it only removes both the testes and ovaries, which is not specific to Testicular Feminization Syndrome. In this condition, the primary issue is the absence of testicular function, which is addressed by removing only the testes.
C. Testis sparing surgery: This option is incorrect as it attempts to preserve the testes, which are responsible for the clinical manifestations of Testicular Feminization Syndrome. Removing the testes is necessary to address the hormonal imbalance and its consequences.
D. Gonadotoxic therapy: This option is incorrect as it refers to the use of toxic substances to damage or destroy the gonads, not a surgical procedure. In Testicular Feminization Syndrome, gonadectomy should be performed to address the hormonal imbalance and its consequences.

**Clinical Pearl:** It is essential for clinicians to accurately diagnose Testicular Feminization Syndrome and perform a targeted gonadectomy (removal of testes) to manage the hormonal imbalance and its clinical manifestations, such as gynecomastia, infertility, and abnormal secondary sexual characteristics. This approach ensures the treatment addresses the root cause of the condition and improves the patient's overall health and wellbeing.