In sub-acute toxicity studies, the drug is given to animals for
Correct Answer: 2-12 weeks
Description: PRECLINICAL TOXICITY STUDIES Acute toxicity studies Single escalating doses are given to small group of animals and the animals are observed for 1-3 days. LD50 is calculated. Organ toxicity is examined by histopathology. Sub-acute toxicity studies Repeated doses of the drug are given for 2-12 weeks. Animal are examined for ove effects, food intake, body weight, hematology Chronic toxicity studies The drug is given for 6-12 months. Animal are examined for ove effects, food intake, body weight, hematology
Category:
Pharmacology
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