Pathology In sickle cell anemia there is substitution of A Valine for glutamic acid at the sixth position of beta chain B Phenylalanine for glutamic acid C Tyrosine for valine at the 6th position at beta chain D All of the above 💡 Explanation In sickle cell anemia there is substitution of ✓ Correct Answer: A. Valine for glutamic acid at the sixth position of beta chain