**Core Concept**
Reye's syndrome is a rare but serious condition that affects the liver and brain, particularly in children and adolescents. The pathophysiology involves mitochondrial dysfunction, particularly in the liver, leading to impaired fatty acid oxidation and energy production.

**Why the Correct Answer is Right**
The hepatic changes in Reye's syndrome are characterized by the accumulation of microvesicular fatty change in the hepatocytes, which is due to the impaired mitochondrial function. This results in the accumulation of fatty acids and their toxic metabolites, leading to liver injury and dysfunction. The mitochondrial dysfunction is thought to be triggered by the use of aspirin and other salicylates, which inhibit the mitochondrial enzyme acyl-CoA dehydrogenase.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not accurately describe the hepatic changes in Reye's syndrome. While there may be some inflammation and hepatocellular injury, the hallmark of Reye's syndrome is the microvesicular fatty change.

**Option B:** This option is incorrect because it is too nonspecific. While liver dysfunction is a key feature of Reye's syndrome, it does not accurately describe the specific histopathological changes.

**Option C:** This option is incorrect because it is not a characteristic feature of Reye's syndrome. While there may be some bile duct injury in certain liver conditions, it is not a hallmark of Reye's syndrome.

**Clinical Pearl / High-Yield Fact**
Reye's syndrome is often associated with the use of aspirin and other salicylates in children and adolescents, particularly during viral infections such as influenza and chickenpox.

**Correct Answer:** D. Microvesicular fatty change